Hyperoxia following cardiac arrest

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Prevalence and factors correlating with hyperoxia exposure following cardiac arrest – an observational single centre study

PURPOSE OF THE STUDY Arterial hyperoxia during care in the intensive care unit (ICU) has been found to correlate with mortality after cardiac arrest (CA). We examined the prevalence of hyperoxia following CA including pre-ICU values and studied differences between those exposed and those not exposed to define predictors of exposure. MATERIALS AND METHODS A retrospective analysis of a prospect...

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Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality.

CONTEXT Laboratory investigations suggest that exposure to hyperoxia after resuscitation from cardiac arrest may worsen anoxic brain injury; however, clinical data are lacking. OBJECTIVE To test the hypothesis that postresuscitation hyperoxia is associated with increased mortality. DESIGN, SETTING, AND PATIENTS Multicenter cohort study using the Project IMPACT critical care database of inte...

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Hyperoxia toxicity after cardiac arrest: What is the evidence?

This review gives an overview of current knowledge on hyperoxia pathophysiology and examines experimental and human evidence of hyperoxia effects after cardiac arrest. Oxygen plays a pivotal role in critical care management as a lifesaving therapy through the compensation of the imbalance between oxygen requirements and supply. However, growing evidence sustains the hypothesis of reactive oxyge...

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Hyperoxia after cardiac arrest may not increase ischemia-reperfusion injury

In the last decade, moderate hypothermia has become the mainstay of treatment in the post-resuscitation period. However, for the damaged brain, optimizing oxygen transport, including arterial oxygenation, may also be important. The current view states that hyperoxia in the immediate post-resuscitation period may worsen cerebral outcome, and international guidelines recommend a target arterial o...

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Delayed encephalopathy following cardiac arrest.

A 46 year old woman suffered a post-operative cardiac arrest associated with prolonged depression of oxygenation and respiration. She made a good initial recovery but one year later insidiously developed symptoms of widespread central nervous system damage compatible with a delayed post-hypoxic encephalopathy. This case is unusual in the length of time between the hypoxic insult and the later d...

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ژورنال

عنوان ژورنال: Intensive Care Medicine

سال: 2015

ISSN: 0342-4642,1432-1238

DOI: 10.1007/s00134-015-3660-1